FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
NPL4
反应性
Human,Rat,Mouse
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
66kD
推荐稀释比
WB 1:500-2000;ELISA 1:5000-20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human protein . at AA range: 270-350
特异性
NPL4 Polyclonal Antibody detects endogenous levels of protein.
基因名称
NPLOC4 KIAA1499 NPL4
蛋白名称
Nuclear protein localization protein 4 homolog (Protein NPL4)
Organism-1
Human
基因ID-1
55666
SwissProt-1
Q8TAT6
Organism-2
Mouse
SwissProt-2
P60670
Organism-3
Rat
SwissProt-3
Q9ES54
背景
domain:Binds ubiquitinated proteins via its RanBP2-type zinc finger.,function:The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.,pathway:Protein degradation; proteasomal ubiquitin-dependent pathway.,similarity:Belongs to the NPL4 family.,similarity:Contains 1 RanBP2-type zinc finger.,subcellular location:Associated with the endoplasmic reticulum and nuclear.,subunit:Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion.,tissue specificity:Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.,
细胞定位
Cytoplasm, cytosol . Endoplasmic reticulum . Nucleus . Associated with the endoplasmic reticulum and nuclear. .
