FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
GCH1
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
27kD
推荐稀释比
WB 1:500-2000;ELISA 1:5000-20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from part region of human protein
特异性
GCH1 Polyclonal Antibody detects endogenous levels of protein.
基因名称
GCH1 DYT5 GCH
蛋白名称
GTP cyclohydrolase 1 (GTP cyclohydrolase I) (GTP-CH-I)
Organism-1
Human
基因ID-1
2643
SwissProt-1
P30793
Organism-2
Mouse
SwissProt-2
Q05915
Organism-3
Rat
SwissProt-3
P22288
背景
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Nucleus .
