FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CHD8
反应性
Human,Rat,Mouse,
应用
IHC,IF
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
283kD
推荐稀释比
IHC 1:50-300;IF 1:50-200
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from part region of human protein
特异性
CHD8 Polyclonal Antibody detects endogenous levels of protein.
基因名称
CHD8 HELSNF1 KIAA1564
蛋白名称
Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)
Organism-1
Human
基因ID-1
57680
SwissProt-1
Q9HCK8
Organism-2
Mouse
SwissProt-2
Q09XV5
Organism-3
Rat
SwissProt-3
Q9JIX5
背景
This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010],
细胞定位
Nucleus . Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites. .
