FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CIDEA
反应性
Human,Mouse
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
24kD
推荐稀释比
WB 1:500-2000;ELISA 1:5000-20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human protein . at AA range: 140-220
特异性
CIDEA Polyclonal Antibody detects endogenous levels of protein.
基因名称
CIDEA
蛋白名称
Cell death activator CIDE-A (Cell death-inducing DFFA-like effector A)
Organism-1
Human
基因ID-1
1149
SwissProt-1
O60543
Organism-2
Mouse
SwissProt-2
O70302
背景
cell death-inducing DFFA-like effector a(CIDEA) Homo sapiens This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010],
细胞定位
Lipid droplet . Nucleus . Enriched at lipid droplet contact sites. Has been shown to localize to mitochondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity). These data could not be confirmed (PubMed:18509062). .
