FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CDA7L
反应性
Human,Rat,Mouse,
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
49kD
推荐稀释比
WB 1:500-2000;ELISA 1:5000-20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human protein . at AA range: 140-220
特异性
CDA7L Polyclonal Antibody detects endogenous levels of protein.
基因名称
CDCA7L HR1 JPO2 R1
蛋白名称
Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2)
Organism-1
Human
基因ID-1
55536
SwissProt-1
Q96GN5
Organism-2
Mouse
SwissProt-2
Q922M5
Organism-3
Rat
SwissProt-3
Q4G059
背景
function:Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.,induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.,miscellaneous:Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.,subcellular location:Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.,subunit:Interacts with MYC and PSIP1.,tissue specificity:Ubiquitous. Overexpressed in medulloblastoma.,
细胞定位
Cytoplasm. Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
