FGF-2 Polyclonal Antibody
¥680.00
Topoisomerase IIα (ABT272) mouse mAb
活动价：
¥880.00
市场价：¥1280.00
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产品规格：
- 50μL
货号：
FAB2602166
- 产品信息
商品描述
靶点-Target
Topo IIα
反应性
Human,Mouse,Rat,
应用
IHC,ELISA
宿主物种-Host Species
Mouse
同种型-Isotype
IgG1,Kappa
修饰-Modification
Unmodified
MW(Calculated)
174kD
MW(Observed)
174kD
推荐稀释比
IHC 1:200-400;ELISA 1:500-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
ABT272
免疫原
Synthesized peptide derived from human Topoisomerase IIα AA range: 1400-1531
特异性
The antibody can specifically recognize human Topoisomerase IIα protein.
基因名称
TOP2A TOP2
蛋白名称
Topoisomerase IIα
别名
DNA topoisomerase 2-alpha;DNA topoisomerase II, alpha isozyme;
Organism-1
Human
基因ID-1
7153
SwissProt-1
P11388
背景
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also pla
细胞定位
Nuclear
