FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
VHL
反应性
Human,
应用
IHC,IF,ELISA
宿主物种-Host Species
Mouse
同种型-Isotype
IgG2b,Kappa
修饰-Modification
Unmodified
MW(Calculated)
24kD,19kD
MW(Observed)
17kD
推荐稀释比
IHC 1:50-200;IF 1:50-200;ELISA 1:500-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
ABT-PVHL
免疫原
Synthesized peptide derived from human pVHL AA range: 150-213
特异性
This antibody detects endogenous levels of pVHL protein.
基因名称
VHL
蛋白名称
Von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)
Organism-1
Human
基因ID-1
7428
SwissProt-1
P40337
背景
von Hippel-Lindau tumor suppressor(VHL) Homo sapiens Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasmic
