FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
p53
反应性
Human,
应用
IHC,WB,IF,ELISA
宿主物种-Host Species
Mouse
同种型-Isotype
IgG2a,Kappa
修饰-Modification
Unmodified
MW(Calculated)
53kD
MW(Observed)
53kD
推荐稀释比
IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein G
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
ABT002
免疫原
Synthesized peptide derived from human protein. AA range:250-393
特异性
The antibody can recognize human wild type and mutant P53 protein. In western blotting of wild type HEK293 cell lysate, the antibody can label a 53 kDa band corresponding to P53, while there is no band detected in P53 knock out HEK293 cell lysate.
基因名称
TP53
蛋白名称
Cellular tumor antigen p53
别名
Antigen NY-CO-13;BCC7;Cellular tumor antigen p53;FLJ92943;LFS1;Mutant tumor protein 53;p53;p53 tumor suppressor;P53_HUMAN;Phosphoprotein p53;Tp53;Transformation related protein 53;TRP53;tumor antigen p55;Tumor protein 53;Tumor protein p53;Tumor suppressor p53
Organism-1
Human
基因ID-1
7157
SwissProt-1
P04637
Organism-2
Mouse
基因ID-2
22059
SwissProt-2
P02340
Organism-3
Rat
基因ID-3
24842
SwissProt-3
P10361
背景
P53 is a tumor suppressor gene located on chromosome 17. The mutation of p53 gene will change its spatial conformation and turn into oncogene, and then lose the regulation of cell growth, apoptosis and DNA repair. The mutation or deletion of p53 gene is the cause of many tumors. Compared with the wild-type protein, the mutant p53 protein has a longer half-life, so it is easier to detect by immunohistochemistry. The p53 mutant protein is expressed in many kinds of tumors, such as breast cancer, gastrointestinal cancer, hepatocellular carcinoma and respiratory tract tumor. It is mainly used for the study of various tumors and can be used as an indicator of tumor prognosis.
细胞定位
Nuclear
