FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Met
反应性
Human,Mouse,Rat,Monkey,
应用
WB,IF,ELISA
宿主物种-Host Species
Mouse
同种型-Isotype
IgG1,Kappa
修饰-Modification
Unmodified
MW(Observed)
150kD
推荐稀释比
WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein G
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PTR1335
免疫原
Synthesized peptide derived from human Met. AA range:1200-1300
特异性
This antibody detects endogenous levels of Met.
基因名称
MET
蛋白名称
Hepatocyte growth factor receptor
别名
MET;Hepatocyte growth factor receptor;HGF receptor;HGF/SF receptor;Proto-oncogene c-Met;Scatter factor receptor;SF receptor;Tyrosine-protein kinase Met
Organism-1
Human
基因ID-1
4233
SwissProt-1
P08581
Organism-2
Mouse
SwissProt-2
P16056
Organism-3
Rat
基因ID-3
24553
SwissProt-3
P97523
背景
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016],
细胞定位
Cytoplasmic
