FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
LIMK-1/2
反应性
Human,Mouse,Rat,
应用
WB,IF,ELISA
宿主物种-Host Species
Mouse
同种型-Isotype
IgG1,Lambda
修饰-Modification
Unmodified
MW(Observed)
68kD,72kD
推荐稀释比
WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein G
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PTR2545
免疫原
Synthesized peptide derived from human LIMK-1/2 AA range: 500-600
特异性
This antibody detects endogenous levels of LIMK-1/2 protein.
基因名称
LIMK1 LIMK
蛋白名称
LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1)
别名
LIM domain kinase 1;LIMK-1;
Organism-1
Human
基因ID-1
3984;3985
SwissProt-1
P53667;P53671
Organism-3
Rat
SwissProt-3
P53669
背景
LIM domain kinase 1(LIMK1) Homo sapiens There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cog
