FGF-2 Polyclonal Antibody
¥680.00
CD40 (PTR1379) recombinant mouse mAb
活动价：
¥880.00
市场价：¥1280.00
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产品规格：
- 50μL
货号：
FAB2601722
- 产品信息
商品描述
靶点-Target
CD40
反应性
Human
应用
Flow Cyt,ELISA
宿主物种-Host Species
Mouse
同种型-Isotype
IgG1,Kappa
修饰-Modification
Unmodified
MW(Observed)
30kD
推荐稀释比
ELISA 1:5000-100000;Flow Cyt 1-2μg/Test
组成
Phosphate-buffered solution
纯化工艺
Recombinant Expression and Affinity purified
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
Please check the information on the tube
克隆性
Monoclonal
克隆号
PTR1379
免疫原
Purified recombinant human CD40.
特异性
This recombinant monoclonal antibody can detects endogenous levels of CD40 protein.
基因名称
CD40
蛋白名称
Tumor necrosis factor receptor superfamily member 5
别名
CD40;TNFRSF5;Tumor necrosis factor receptor superfamily member 5;B-cell surface antigen CD40;Bp50;CD40L receptor;CDw40;CD antigen CD40
Organism-1
Human
基因ID-1
958
SwissProt-1
P25942
Organism-2
Mouse
基因ID-2
21939
SwissProt-2
P27512
背景
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIG
细胞定位
[Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.
