FGF-2 Polyclonal Antibody
¥680.00
CD284/TLA4 (PTR1381) recombinant mouse mAb
活动价：
¥880.00
市场价：¥1280.00
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产品规格：
- 50μL
货号：
FAB2601698
- 产品信息
商品描述
靶点-Target
CD284
反应性
Human
应用
Flow Cyt,ELISA
宿主物种-Host Species
Mouse
同种型-Isotype
IgG1,Kappa
修饰-Modification
Unmodified
MW(Observed)
95kD
推荐稀释比
ELISA 1:5000-100000;Flow Cyt 1-2μg/Test
组成
Phosphate-buffered solution
纯化工艺
Recombinant Expression and Affinity purified
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
Please check the information on the tube
克隆性
Monoclonal
克隆号
PTR1381
免疫原
Purified recombinant human CD284
特异性
This recombinant monoclonal antibody can detects endogenous levels of CD284 protein.
基因名称
TLR4
蛋白名称
Toll-like receptor 4
别名
TLR4;Toll-like receptor 4;hToll;CD antigen CD284
Organism-1
Human
基因ID-1
7099
SwissProt-1
O00206
Organism-2
Mouse
基因ID-2
21898
SwissProt-2
Q9QUK6
背景
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
细胞定位
Cell membrane ; Single-pass type I membrane protein . Early endosome . Cell projection, ruffle . Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis (PubMed:20037584). Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation. .
