FGF-2 Polyclonal Antibody
¥680.00
Collagen IV mouse Monoclonal Antibody(8E5)
活动价：
¥880.00
市场价：¥1280.00
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产品规格：
- 50μL
货号：
FAB2601645
- 产品信息
商品描述
靶点-Target
Collagen IV
反应性
Human,Mouse,Rat
应用
IF,IHC
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
161kD
推荐稀释比
IF 1:50-200;IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Monoclonal
克隆号
8E5
免疫原
Synthesized peptide derived from human Collagen Type IV AA range: 1600-1669
特异性
The antibody detects endogenous Collagen IV protein
基因名称
COL4A1
蛋白名称
Collagen alpha-1(IV) chain [Cleaved into: Arresten]
别名
Collagen alpha-1;IV;chain [Cleaved into: Arresten]
Organism-1
Human
基因ID-1
1282
SwissProt-1
p02462
Organism-2
Mouse
SwissProt-2
P02463
背景
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
细胞定位
Secreted, extracellular space, extracellular matrix, basement membrane .
