FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
AKT1/2/3
反应性
Human,Mouse,Rat,
应用
WB,IP,IF,ELISA
宿主物种-Host Species
Mouse
同种型-Isotype
IgG3,Kappa
修饰-Modification
Unmodified
MW(Observed)
60kD
推荐稀释比
WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein G
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Monoclonal
克隆号
PTR2314
免疫原
Synthetic Peptide of human AKT at AA range of human 400-480 AA range: 370-477
特异性
This antibody detects endogenous levels of Akt 1/2/3 protein.
基因名称
AKT1/AKT2/AKT3
蛋白名称
AKT1
别名
AKT1
Organism-1
Human
基因ID-1
207;208;10000
SwissProt-1
P31749;P31751;Q9Y243
Organism-2
Mouse
SwissProt-2
P31750
背景
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
