FGF-2 Polyclonal Antibody
¥680.00
a-actinin Monoclonal Antibody(4A12)
活动价：
¥880.00
市场价：¥1280.00
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产品规格：
- 50μL
货号：
FAB2601615
- 产品信息
商品描述
靶点-Target
Actinin-α1
反应性
Human,Rat,Mouse
应用
WB,IHC,IF
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
103kD
推荐稀释比
IHC 1:200-400;IF/ICC1:200-400;WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Monoclonal
克隆号
4A12
免疫原
Recombinant Protein of a-actinin of ACTN1
特异性
a-actinin Monoclonal Antibody(4A12) detects endogenous levels of ACTN1
基因名称
ACTN1
蛋白名称
ACTN1
别名
ACTN1
Organism-1
Human
基因ID-1
87
SwissProt-1
P12814
Organism-2
Mouse
SwissProt-2
Q7TPR4
Organism-3
Rat
SwissProt-3
Q9Z1P2
背景
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Cell membrane . Cell junction . Cell projection, ruffle . Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures. .
