FGF-2 Polyclonal Antibody
¥680.00
Active Caspase-3 Monoclonal Antibody(5E1)
活动价：
¥880.00
市场价：¥1280.00
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产品规格：
- 50μL
货号：
FAB2601571
- 产品信息
商品描述
靶点-Target
Caspase-3
反应性
Human,Mouse,Rat,Chicken
应用
IF,WB,IP,IHC
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
17kD
推荐稀释比
IF 1:50-200;WB 1:500-1000;IHC 1:100-200
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
5E1
免疫原
Recombinant Protein of Active Caspase-3
特异性
The antibody detects endogenous cleaved Caspase-3 protein p17 isoform.
基因名称
CASP3
蛋白名称
Caspase3
别名
CASP3;CPP32;Caspase-3;CASP-3;Apopain;Cysteine protease CPP32;CPP-32;Protein Yama;SREBP cleavage activity 1;SCA-1
Organism-1
Human
基因ID-1
836
SwissProt-1
P42574
Organism-2
Mouse
SwissProt-2
P70677
Organism-3
Rat
SwissProt-3
P55213
背景
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm.
