FGF-2 Polyclonal Antibody
¥680.00
Pan Methylated Lysine Monoclonal Antibody(Mix)
活动价：
¥880.00
市场价：¥1280.00
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产品规格：
- 50μL
货号：
FAB2601569
- 产品信息
商品描述
靶点-Target
Pan Methylated Lysine
反应性
Species independent
应用
WB,IHC,IF
宿主物种-Host Species
Mouse
修饰-Modification
Pan Methyl
推荐稀释比
WB 1:1000-2000;IHC 1:200-500;IF 1:50-200
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Conjugated Protein
特异性
The antibody detects endogenous Pan Methylated Lysine protein.
背景
Methylation of lysine residues is a common regulatory posttranslational modification (PTM) that results in the mono-, di-, or tri-methylation of lysine at ε-amine groups by protein lysine methyltransferases (PKMTs). Two PKMT groups are recognized based on structure and catalytic mechanism: class I methyltransferases or seven β strand enzymes, and SET domain-containing class V methyltransferases. Both use the methyl donor S-adenosyl-L-methionine to methylate histone and non-histone proteins. Class I methyltransferases methylate amino acids, DNA, and RNA. Six methyl-lysine-interacting protein families are distinguished based on binding domains: mBT, PHD finger, Tudor, PWWP, WD40 repeat, and chromodomains. Many of these display differential binding preferences based on lysine methylation state. KDM1 subfamily lysine demethylases catalyze demethylation of mono- and di-methyl lysines, while 2-oxoglutarate-dependent JmjC (KDM2-7) subfamily enzymes also modify tri-methyl lysine residues.
