FGF-2 Polyclonal Antibody
¥680.00
Caspase-8 Monoclonal Antibody(2G12)
活动价：
¥880.00
市场价：¥1280.00
一键复制产品信息
产品规格：
- 50μL
货号：
FAB2601562
- 产品信息
商品描述
靶点-Target
Caspase-8
反应性
Human,Mouse,Rat
应用
WB,IF,IHC
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
43,57kD
推荐稀释比
WB 1:1000-2000;IHC 1:200-500;IF 1:200
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
2G12
免疫原
Recombinant Protein of Caspase-8
特异性
The antibody detects endogenous Caspase-8 protein.
基因名称
CASP8
蛋白名称
Caspase8
别名
CASP8;MCH5;Caspase-8;CASP-8;Apoptotic cysteine protease;Apoptotic protease Mch-5;CAP4;FADD-homologous ICE/ced-3-like protease;FADD-like ICE;FLICE;ICE-like apoptotic protease 5;MORT1-associated ced-3 homolog;MACH
Organism-1
Human
基因ID-1
841
SwissProt-1
Q14790
Organism-2
Mouse
SwissProt-2
O89110
背景
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alt
细胞定位
Cytoplasm . Nucleus .
