FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PCSK9
反应性
Human
应用
IHC
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
74kD
推荐稀释比
IHC1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Monoclonal
克隆号
5G4
免疫原
Synthesized peptide derived from human PCSK9
特异性
This antibody detects endogenous levels of PCSK9 at Human, Mouse,Rat
基因名称
PCSK9 NARC1 PSEC0052
蛋白名称
PCSK9
别名
Proprotein convertase subtilisin/kexin type 9;Neural apoptosis-regulated convertase 1;NARC-1;Proprotein convertase 9;PC9;Subtilisin/kexin-like protease PC9;
Organism-1
Human
基因ID-1
255738
SwissProt-1
Q8NBP7
Organism-2
Mouse
基因ID-2
100102
SwissProt-2
Q80W65
Organism-3
Rat
基因ID-3
298296
SwissProt-3
P59996
背景
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],
细胞定位
Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.
