FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Cofilin
反应性
Human,Mouse,Rat
应用
IHC,WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
19kD
推荐稀释比
IHC1:50-200;WB 1:1000-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Monoclonal
免疫原
Synthesized peptide derived from human Cofilin
特异性
This antibody detects endogenous levels of Cofilin at Human, Mouse,Rat
基因名称
CFL1 CFL
蛋白名称
Cofilin
别名
Cofilin-1;18 kDa phosphoprotein;p18;Cofilin, non-muscle isoform;
Organism-1
Human
基因ID-1
1072
SwissProt-1
P23528
Organism-2
Mouse
基因ID-2
12631
SwissProt-2
P18760
Organism-3
Rat
基因ID-3
29271
SwissProt-3
P45592
背景
cofilin 1(CFL1) Homo sapiens The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004],
细胞定位
Nucleus matrix . Cytoplasm, cytoskeleton . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium . Cell projection, growth cone . Cell projection, axon . Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
