FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
AMPKβ2
反应性
Human,Mouse,Rat
应用
IHC,WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
30kD
推荐稀释比
IHC1:50-200;WB 1:1000-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Monoclonal
免疫原
Synthesized peptide derived from human AMPKβ2
特异性
This antibody detects endogenous levels of AMPKβ2 at Human, Mouse,Rat
基因名称
PRKAB2
蛋白名称
AMPKβ2
别名
5'-AMP-activated protein kinase subunit beta-2;AMPK subunit beta-2;
Organism-1
Human
基因ID-1
5565
SwissProt-1
O43741
Organism-2
Mouse
基因ID-2
108097
SwissProt-2
Q6PAM0
Organism-3
Rat
基因ID-3
64562
SwissProt-3
Q9QZH4
背景
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],
细胞定位
nucleoplasm,cytosol,nucleotide-activated protein kinase complex,
