FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
AMPKγ1
反应性
Human,Mouse,Rat
应用
IHC,WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
38kD
推荐稀释比
IHC1:50-200;WB 1:1000-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Monoclonal
克隆号
5H5
免疫原
Synthesized peptide derived from human AMPK γ1
特异性
This antibody detects endogenous levels of AMPK γ1 at Human, Mouse,Rat
基因名称
PRKAG1
蛋白名称
AMPK γ1
别名
5'-AMP-activated protein kinase subunit gamma-1;AMPK gamma1;AMPK subunit gamma-1;AMPKg;
Organism-1
Human
基因ID-1
5571
SwissProt-1
P54619
Organism-2
Mouse
基因ID-2
19082
SwissProt-2
O54950
Organism-3
Rat
基因ID-3
25520
SwissProt-3
P80385
背景
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
细胞定位
nucleoplasm,cytosol,membrane,nucleotide-activated protein kinase complex,extracellular exosome,
