FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
ERCC1
反应性
Human
应用
WB,IHC,IF,
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
36kD
推荐稀释比
IHC: 100-300;WB 1:1000;IF 1:50-200
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
1B10
免疫原
Synthetic Peptide of ERCC1
特异性
The antibody detects endogenous ERCC1 proteins.
基因名称
ERCC1
蛋白名称
DNA excision repair protein ERCC-1
别名
ERCC1;DNA excision repair protein ERCC-1
Organism-1
Human
基因ID-1
2067
SwissProt-1
P07992
Organism-2
Mouse
基因ID-2
13870
SwissProt-2
P07903
背景
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein ge
细胞定位
[Isoform 1]: Nucleus .; [Isoform 2]: Cytoplasm . Nucleus .; [Isoform 3]: Nucleus .; [Isoform 4]: Nucleus .
