FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Caspase-9
反应性
Human,Mouse,Rat,chicken
应用
WB,IHC,IF,IP
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
46kD
推荐稀释比
WB 1:1000-5000;IP 1:200;IF 1:200;IHC 1:50-300
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
3-20
免疫原
Synthetic Peptide of Caspase 9
特异性
The antibody detects endogenous Caspase 9 protein.
基因名称
CASP9
蛋白名称
Caspase9
别名
CASP9;MCH6;Caspase-9;CASP-9;Apoptotic protease Mch-6;Apoptotic protease-activating factor 3;APAF-3;ICE-like apoptotic protease 6;ICE-LAP6
Organism-1
Human
基因ID-1
842
SwissProt-1
P55211
背景
CASP9 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 9 can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. Caspase 9 is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
细胞定位
nucleus,mitochondrion,cytosol,apoptosome,
