FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
FH
反应性
Human,Mouse,Rat
应用
WB,IHC,IF
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
50kD
推荐稀释比
WB 1:3000;IF 1:200;IHC 1:50-300
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
7F1
免疫原
Synthetic Peptide of FH
特异性
The antibody detects endogenous FH proteins.
基因名称
FH
蛋白名称
Fumarate hydratase, mitochondrial
别名
Fumarate hydratase, mitochondrial;Fumarase;
Organism-1
Human
基因ID-1
2271
SwissProt-1
P07954
Organism-2
Mouse
基因ID-2
14194
SwissProt-2
P97807
Organism-3
Rat
SwissProt-3
P14408
背景
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008],
细胞定位
[Isoform Mitochondrial]: Mitochondrion .; [Isoform Cytoplasmic]: Cytoplasm, cytosol . Nucleus . Chromosome . Translocates to the nucleus in response to DNA damage: localizes to DNA double-strand breaks (DSBs) following phosphorylation by PRKDC. .
