FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CD4
反应性
Human,Mouse,Rat
应用
IHC
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
51kD
推荐稀释比
IHC 1:200
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
11A1
免疫原
Synthetic Peptide of CD4
特异性
The antibody detects endogenous CD4 proteins.
基因名称
CD4
蛋白名称
T-cell surface glycoprotein CD4
别名
CD4;T-cell surface glycoprotein CD4;T-cell surface antigen T4/Leu-3;CD4
Organism-1
Human
基因ID-1
920
SwissProt-1
P01730
Organism-2
Mouse
基因ID-2
12504
SwissProt-2
P06332
Organism-3
Rat
基因ID-3
24932
SwissProt-3
P05540
背景
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010],
细胞定位
Cell membrane ; Single-pass type I membrane protein . Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
