FGF-2 Polyclonal Antibody
¥680.00
Aquaporin 4 Monoclonal Antibody(4H1)
活动价：
¥880.00
市场价：¥1280.00
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产品规格：
- 50μL
货号：
FAB2601430
- 产品信息
商品描述
靶点-Target
AQP4
反应性
Human,Mouse,Rat
应用
WB,IHC,IF
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
48kD
推荐稀释比
WB 1:1000;IF 1:100-200;IHC 1:50-300
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
4H1
免疫原
Synthetic Peptide of Aquaporin 4
特异性
The antibody detects endogenous Aquaporin 4 proteins.
基因名称
AQP4
蛋白名称
Aquaporin-4
别名
AQP4;Aquaporin-4;AQP-4;Mercurial-insensitive water channel;MIWC;WCH4
Organism-1
Human
基因ID-1
361
SwissProt-1
P55087
Organism-2
Mouse
基因ID-2
11829
SwissProt-2
P55088
Organism-3
Rat
基因ID-3
25293
SwissProt-3
P47863
背景
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015],
细胞定位
Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein . Endosome membrane . Cell membrane, sarcolemma ; Multi-pass membrane protein . Cell projection . Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane. Detected on brain astrocyte processes and astrocyte endfeet close to capillaries. .
