FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CD45
反应性
Human
应用
IF,WB,IHC,
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
147kD
推荐稀释比
IF 1:50-200;WB 1:2000;IHC 1:50-300
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
12A9
免疫原
Synthetic Peptide of CD45
特异性
The antibody detects endogenous CD45 proteins.
基因名称
PTPRC
蛋白名称
Receptor-type tyrosine-protein phosphatase C
别名
PTPRC;CD45;Receptor-type tyrosine-protein phosphatase C;Leukocyte common antigen;L-CA;T200;CD45
Organism-1
Human
基因ID-1
5788
SwissProt-1
P08575
Organism-2
Mouse
SwissProt-2
P06800
Organism-3
Rat
基因ID-3
24699
SwissProt-3
P04157
背景
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which enc
细胞定位
Cell membrane ; Single-pass type I membrane protein . Membrane raft . Colocalized with DPP4 in membrane rafts. .
