FGF-2 Polyclonal Antibody
¥680.00
PCNA Monoclonal Antibody(12D10), AbFluor 647 Conjugated
活动价：
¥880.00
市场价：¥1280.00
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产品规格：
- 50μL
货号：
FAB2601317
- 产品信息
商品描述
靶点-Target
PCNA
反应性
Human,Rat,Mouse
应用
WB,IF,IHC
宿主物种-Host Species
Mouse
同种型-Isotype
IgG1
偶联-Conjugate
AbFluor 647
修饰-Modification
Unmodified
MW(Observed)
30-33kD
推荐稀释比
Optimal working dilutions should be determined experimentally by the investigator;Suggested starting dilutions are as follows:IHC 1:200;IF 1:200.
组成
Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
Stable for one year at -15°C to -25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Store in dark.
浓度
1mg/ml
克隆性
Monoclonal
克隆号
12D10
特异性
PCNA Monoclonal Antibody(12D10) AbFluor™ 647 Conjugated specially designed for your Immunofluorescence analysis.
基因名称
PCNA
蛋白名称
Proliferating cell nuclear antigen
别名
PCNA;Proliferating cell nuclear antigen;PCNA;Cyclin
Organism-1
Human
基因ID-1
5111
SwissProt-1
P12004
背景
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .
