FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
FADD
反应性
Human
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
23kD
推荐稀释比
WB 1:1000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human FADD protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of FADD and does not cross-react with related proteins.
基因名称
fadd
别名
FADD;FADD protein;FADD_HUMAN;Fas;TNFRSF6;associated via death domain;Fas associated via death domain;Fas associating death domain containing protein;Fas associating death domain containing protein;Fas associating protein;Fas associating protein with death domain;Fas associating protein with death domain;Fas TNFRSF6 associated via death domain;FAS-associated death domain protein;FAS-associating death domain-containing protein;FasTNFRSF6 associated via death domain;FasTNFRSF6 associated via death domain;GIG 3;GIG3;Growth inhibiting gene 3 protein;Growth-inhibiting gene 3 protein;H sapiens mRNA for mediator of receptor induced toxicity;H sapiens mRNA for mediator of receptor induced toxicity;Mediator of receptor induced toxicity;Mediator of receptor induced toxicity;MGC8528;MGC8528;MORT 1;MORT1;MORT1;Protein FADD.
Organism-1
Human
基因ID-1
8772
SwissProt-1
Q13158
Organism-2
Mouse
SwissProt-2
Q61160
背景
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008],
细胞定位
cytoplasm,cytosol,plasma membrane,death-inducing signaling complex,CD95 death-inducing signaling complex,neuron projection,cell body,membrane raft,ripoptosome,
