FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
TLR3
反应性
Transfected
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
104kD
推荐稀释比
WB 1:1000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human Toll-Like Receptor 3 protein fragments expressed in E.coli.
特异性
Transfected Only.
基因名称
tlr3
别名
CD283;CD283 antigen;IIAE2;TLR 3;Tlr3;TLR3_HUMAN;Toll Like Receptor 3;Toll-like receptor 3.
Organism-1
Human
基因ID-1
7098
SwissProt-1
O15455
Organism-2
Mouse
SwissProt-2
Q99MB1
背景
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate
细胞定位
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome .
