FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
AIF
反应性
Human
应用
WB,IF
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
67kD
推荐稀释比
WB 1:1000;ICC 1:200;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human AIF protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of AIF and does not cross-react with related proteins.
基因名称
aifm1
别名
AIFM1;AIFM1_HUMAN;Apoptosis inducing factor 1, mitochondrial;Apoptosis inducing factor;Apoptosis inducing factor, mitochondrion associated, 1;Apoptosis-inducing factor 1;CMTX4;COWCK;COXPD6;Harlequin;Hq;mAIF;MGC111425;MGC5706;mitochondrial;Neuropathy, axonal motor-sensory, with deafness and mental retardation;neuropathy, axonal, motor-sensory with deafness and mental retardation;Cowchock syndrome;PDCD 8;PDCD8;Programmed cell death 8;apoptosis inducing factor;Programmed cell death 8;Programmed cell death 8 isoform 1;Programmed cell death 8 isoform 2;Programmed cell death 8 isoform 3;Programmed cell death protein 8;Programmed cell death protein 8 mitochondrial;Programmed cell death protein 8 mitochondrial precursor;Striatal apoptosis inducing factor.
Organism-1
Human
基因ID-1
9131
SwissProt-1
O95831
Organism-2
Mouse
SwissProt-2
Q9Z0X1
背景
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome
细胞定位
Mitochondrion intermembrane space . Mitochondrion inner membrane. Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis (PubMed:15775970). Colocalizes with EIF3G in the nucleus and perinuclear region (PubMed:17094969). .; [Isoform 3]: Mitochondrion intermembrane space . Mitochondrion inner membrane . Has a stronger membrane anchorage than isoform 1. .; [Isoform 4]: Mitochondrion . Cytoplasm, cytosol . In pro-apoptotic conditions, is released from mitochondria to cytosol in a calpain/cathepsin-dependent manner. .; [Isoform 5]: Cytoplasm .
