FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
SHP-1
反应性
Human
应用
WB,IP
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
68kD
推荐稀释比
WB 1:1000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human SHP-1 protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of SHP-1 and does not cross-react with related proteins.
基因名称
ptpn6
别名
70 kda SHP1L protein;70Z-SHP;HCP;HCPH;Hematopoietic cell phosphatase;Hematopoietic cell protein tyrosine phosphatase;Hematopoietic cell protein-tyrosine phosphatase;HPTP1C;Protein tyrosine phosphatase 1C;Protein tyrosine phosphatase non receptor type 6;Protein tyrosine phosphatase SHP1;Protein-tyrosine phosphatase 1C;protein-tyrosine phosphatase SHP 1;Protein-tyrosine phosphatase SHP-1;PTN6_HUMAN;PTP 1C;PTP-1C;PTP1C;PTPN6;SH PTP 1;SH PTP1;SH-PTP1;SHP 1;SHP 1L;SHP1;SHP1L;tyrosine protein phosphatase non receptor type 6;Tyrosine-protein phosphatase non-receptor type 6.
Organism-1
Human
基因ID-1
5777
SwissProt-1
P29350
Organism-2
Mouse
SwissProt-2
P29351
背景
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul
细胞定位
Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. .
