FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
eIF2α
反应性
Human,Mouse,Rat
应用
WB,IF,IP
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
38kD
推荐稀释比
WB 1:1000;ICC 1:200;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human eIF2α protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of eIF2α and does not cross-react with related proteins.
基因名称
eif2s1
别名
Dmel\CG6376;Dmel_CG6376;drosE2F1;E;Sev-CycE;3A;E;var;3-93E;E2-promoter binding facto;E2F 1;E2F transcription factor 1;E2F-1;E2f-PA;E2f-PB;E2f-PC;E2F1;E2f1 E2F transcription factor 1;E2F1_HUMAN;Evar;3;164;KIAA4009;l;3;07172;l;3;j3B1;l;3;j3C2;l;3;rM729;mKIAA4009;OTTHUMP00000030661;PBR3;PRB binding protein E2F 1;PRB-binding protein E2F-1;RBAP 1;RBAP-1;RBAP1;RBBP-3;RBBP3;RBP 3;RBP3;Retinoblastoma-associated protein 1;Retinoblastoma-binding protein 3;Transcription factor E2F1.
Organism-1
Human
基因ID-1
1965
SwissProt-1
P05198
Organism-2
Mouse
SwissProt-2
Q6ZWX6
背景
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010],
细胞定位
Cytoplasm, Stress granule . Colocalizes with NANOS3 in the stress granules. .
