FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Annexin I
反应性
Human,Mouse,Rat,Monkey
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
38kD
推荐稀释比
WB 1:1000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human Annexin A1 beta protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of Annexin A1 and does not cross-react with related proteins.
基因名称
anxa1
别名
Annexin 1;Annexin A1;Annexin I;lipocortin I;Annexin I;Annexin-1;AnnexinA1;AnnexinI;ANX 1;ANX A1;ANX1;ANXA 1;ANXA1;ANXA1 protein;ANXA1_HUMAN;Calpactin 2;Calpactin II;Calpactin-2;CalpactinII;Chromobindin 9;Chromobindin-9;Chromobindin9;HGNC:533;Lipocortin 1;Lipocortin I;Lipocortin1;LipocortinI;LPC 1;LPC1;p35;Phospholipase A2 inhibitory protein.
Organism-1
Human
基因ID-1
301
SwissProt-1
P04083
Organism-2
Mouse
SwissProt-2
P10107
背景
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014],
细胞定位
Nucleus . Cytoplasm . Cell projection, cilium . Cell membrane . Membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Basolateral cell membrane . Apical cell membrane . Lateral cell membrane . Secreted . Secreted, extracellular space . Cell membrane ; Peripheral membrane protein ; Extracellular side . Secreted, extracellular exosome . Cytoplasmic vesicle, secretory vesicle lumen . Cell projection, phagocytic cup . Early endosome . Cytoplasmic vesicle membrane ; Peripheral membrane protein . Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Alternatively, the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in the protein translocation from the cytoplasm into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). .
