FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
E2F-1
反应性
Human,Rat
应用
WB,IF,IP
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
60kD
推荐稀释比
WB 1:500;ICC 1:100;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human E2F-1 protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of E2F-1 and does not cross-react with related proteins.
基因名称
e2f1
别名
Dmel\CG6376;Dmel_CG6376;drosE2F1;E;Sev-CycE;3A;E;var;3-93E;E2-promoter binding facto;E2F 1;E2F transcription factor 1;E2F-1;E2f-PA;E2f-PB;E2f-PC;E2F1;E2f1 E2F transcription factor 1;E2F1_HUMAN;Evar;3;164;KIAA4009;l;3;07172;l;3;j3B1;l;3;j3C2;l;3;rM729;mKIAA4009;OTTHUMP00000030661;PBR3;PRB binding protein E2F 1;PRB-binding protein E2F-1;RBAP 1;RBAP-1;RBAP1;RBBP-3;RBBP3;RBP 3;RBP3;Retinoblastoma-associated protein 1;Retinoblastoma-binding protein 3;Transcription factor E2F1.
Organism-1
Human
基因ID-1
1869
SwissProt-1
Q01094
Organism-2
Mouse
SwissProt-2
Q61501
背景
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can media
细胞定位
Nucleus .
