FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Lamin A/C
反应性
Human
应用
WB,IF
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
74/63kD
推荐稀释比
WB 1:1000;ICC 1:200;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human LMNA protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of Lamin A/C and does not cross-react with related proteins.
基因名称
lmna
别名
70 kDa lamin;Cardiomyopathy dilated 1A;autosomal dominant;CDCD1;CDDC;CMD1A;CMT2B1;EMD2;FPL;FPLD;FPLD2;HGPS;IDC;LAMIN A;lamin A/C;Lamin A/C like 1;Lamin;LAMIN C;Lamin-A/C;LDP1;LFP;LGMD1B;Limb girdle muscular dystrophy 1B;autosomal dominant;LMN 1;LMN A;LMN C;LMN1;LMNA;LMNA_HUMAN;LMNC;LMNL1;Prelamin A/C;PRO1;Renal carcinoma antigen NY REN 32;Renal carcinoma antigen NY-REN-32;Renal carcinoma antigen NYREN32.
Organism-1
Human
基因ID-1
4000
SwissProt-1
P02545
Organism-2
Mouse
SwissProt-2
P48678
背景
lamin A/C(LMNA) Homo sapiens The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012],
细胞定位
Nucleus . Nucleus envelope . Nucleus lamina. Nucleus, nucleoplasm. Nucleus matrix . Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleavage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C.; [Isoform C]: Nucleus speckle .
