FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
EGFR
反应性
Human,Monkey
应用
WB,IHC,ICC,IP
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
175kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:5000;IP 1:50-100
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human EGFR protein fragments expressed in E.coli.
特异性
The antibody detects endogenous level of total EGFR and does not cross-react with related proteins.
基因名称
egfr
别名
Avian erythroblastic leukemia viral;v erb b;oncogene homolog;Cell growth inhibiting protein 40;Cell proliferation inducing protein 61;EGF R;EGFR;EGFR_HUMAN;Epidermal growth factor receptor;avian erythroblastic leukemia viral;v erb b;oncogene homolog;Epidermal growth factor receptor;erythroblastic leukemia viral;v erb b;oncogene homolog avian;Epidermal growth factor receptor;erbb 1;Erbb;Erbb1;ERBB1;Errp;HER1;mENA;Oncogene ERBB;PIG61;Proto-oncogene c-ErbB-1;Receptor tyrosine protein kinase ErbB 1;Receptor tyrosine-protein kinase ErbB-1;Urogastrone;wa2;Wa5.
Organism-1
Human
基因ID-1
1956
SwissProt-1
P00533
Organism-2
Mouse
SwissProt-2
Q01279
背景
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016],
细胞定位
Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). .; [Isoform 2]: Secreted.
