FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
JNK1
反应性
Human,Mouse,Rat
应用
WB,IF
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
46,54kD
推荐稀释比
WB 1:1000;ICC 1:100;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human JNK1 protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of JNK1 and does not cross-react with related proteins.
基因名称
mapk8
别名
AI849689;c Jun N terminal kinase 1;C-JUN kinase 1;c-Jun N-terminal kinase 1;JAK 1A;JAK1A;JNK 1;JNK 46;JNK;JNK-46;JNK1A2;JNK21B1/2;MAP kinase 8;MAPK 8;MAPK8;Mitogen activated protein kinase 8;Mitogen-activated protein kinase 8;MK08_HUMAN;p54 gamma;PRKM 8;PRKM8;Protein kinase JNK1;Protein kinase, mitogen-activated, 8;SAPK 1;SAPK gamma;SAPK1;Stress activated protein kinase JNK1;Stress-activated protein kinase 1;Stress-activated protein kinase JNK1;Tyrosine protein kinase JAK1 .
Organism-1
Human
基因ID-1
5599
SwissProt-1
P45983
Organism-2
Mouse
SwissProt-2
Q91Y86
背景
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spl
细胞定位
Cytoplasm . Nucleus . Cell junction, synapse . In the cortical neurons, predominantly cytoplasmic and associated with the Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses (By similarity). Colocalizes with POU5F1 in the nucleus. .
