FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Rad23B
反应性
Human,Mouse,Rat,Monkey,Hamster
应用
WB,ICC,IHC
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
58kD
推荐稀释比
WB 1:1000;ICC 1:100
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human hHR23b protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of hHR23b and does not cross-react with related proteins.
基因名称
hr23b
别名
hHR 23b;hHR23B;HR 23B;HR23B;mHR 23B;mHR23B;P58;RAD 23B;RAD23;S. cerevisiae;homolog B;RAD23 homolog B;S. cerevisiae;RAD23 homolog B;RAD23 yeast homolog of B;RAD23B;RD23B_HUMAN;UV excision repair protein RAD23 homolog B;XP C repair complementing complex 58 kDa;XP C repair complementing complex 58 kDa protein;XP C repair complementing protein;XP-C repair-complementing complex 58 kDa protein;XPC repair complementing complex 58 kDa;XPC repair complementing complex 58 kDa protein;XPC repair complementing protein.
Organism-1
Human
基因ID-1
5887
SwissProt-1
P54727
Organism-2
Mouse
SwissProt-2
P54728
背景
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011],
细胞定位
Nucleus. Cytoplasm. The intracellular distribution is cell cycle dependent. Localized to the nucleus and the cytoplasm during G1 phase. Nuclear levels decrease during S-phase; upon entering mitosis, relocalizes in the cytoplasm without association with chromatin.
