FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
ZAP-70
反应性
Human
应用
WB,IP
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
70kD
推荐稀释比
WB 1:1000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human ZAP-70 protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of ZAP-70 and does not cross-react with related proteins.
基因名称
zap70
别名
70 kDa zeta associated protein;70 kDa zeta-associated protein;FLJ17670;FLJ17679;Selective T cell defect;SRK;STD;Syk related tyrosine kinase;Syk-related tyrosine kinase;Truncated ZAP kinase;Tyrosine protein kinase ZAP70;Tyrosine-protein kinase ZAP-70;TZK;ZAP 70;ZAP-70;ZAP70;ZAP70_HUMAN;Zeta chain associated protein kinase 70kD;Zeta chain associated protein kinase 70kDa;Zeta chain associated protein kinase 70kDa isoform 1;Zeta chain associated protein kinase 70kDa isoform 2;Zeta chain TCR associated protein kinase 70kD;Zeta chain TCR associated protein kinase 70kDa.
Organism-1
Human
基因ID-1
7535
SwissProt-1
P43403
Organism-2
Mouse
SwissProt-2
P43404
背景
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein . In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes (By similarity). .
