FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PCNA
反应性
Human,Mouse,Monkey,Rat,Hamster
应用
WB,IP,ICC,IHC
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
30-33kD
推荐稀释比
WB 1:1000;ICC 1:100
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human PCNA protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of PCNA and does not cross-react with related proteins.
基因名称
pcna
别名
Cyclin;DNA polymerase delta auxiliary protein;HGCN8729;MGC8367;Mutagen-sensitive 209 protein;OTTHUMP00000030189;OTTHUMP00000030190;PCNA;Pcna/cyclin;PCNA_HUMAN;PCNAR;Polymerase delta accessory protein;Proliferating Cell Nuclear Antigen.
Organism-1
Human
基因ID-1
5111
SwissProt-1
P12004
Organism-2
Mouse
SwissProt-2
P17918
背景
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .
