FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Noggin
应用
WB,ICC
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
26kD
推荐稀释比
WB 1:1000;ICC 1:100
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human Noggin protein fragments expressed in E.coli.
特异性
Transfected Only.
基因名称
nog
别名
NOG;NOGG_HUMAN;Noggin;SYM 1;SYM1;Symphalangism 1;proximal;Synostoses;multiple;syndrome 1;SYNS 1;SYNS1.
Organism-1
Human
基因ID-1
9241
SwissProt-1
Q13253
Organism-2
Mouse
SwissProt-2
P97466
背景
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and mu
细胞定位
Secreted.
