FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CYP17A1
反应性
Human
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
60kD
推荐稀释比
WB 1:1000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human Cytochrome P450 17A1 protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of Cytochrome P450 17A1 and does not cross-react with related proteins.
基因名称
cyp17a1
别名
20 lyase;CP17A_HUMAN;CPT7;CYP17;CYP17A1;CYPXVII;Cytochrome P450 17A1;Cytochrome P450 family 17;Cytochrome P450 family 17 subfamily A polypeptide 1;Cytochrome p450 subfamily XVII;steroid 17 alpha hydroxylase;adrenal hyperplasia;Cytochrome p450 XVIIA1;Cytochrome P450-C17;Cytochrome P450c17;OTTHUMP00000020382;P450 C17;P450c17;S17AH;Steroid 17 alpha hydroxylase/17,20 lyase;Steroid 17 alpha monooxygenase;Steroid 17-alpha-hydroxylase/17;Steroid 17-alpha-monooxygenase.
Organism-1
Human
基因ID-1
1586
SwissProt-1
P05093
Organism-2
Mouse
SwissProt-2
P27786
背景
cytochrome P450 family 17 subfamily A member 1(CYP17A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008],
细胞定位
Endoplasmic reticulum membrane . Microsome membrane .
