FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
HDAC3
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
49kD
推荐稀释比
WB 1:1000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human HDAC3 protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of HDAC3 and does not cross-react with related proteins.
基因名称
hdac3
别名
HD 3;HD3;HDAC 3;HDAC3;HDAC3_HUMAN;Histone deacetylase 3;HD3;RPD3-2;histone deacetylase 3;RPD 3;RPD3 2;RPD3;RPD3-2;SMAP 45;SMAP45.
Organism-1
Human
基因ID-1
8841
SwissProt-1
O15379
Organism-2
Mouse
SwissProt-2
O88895
背景
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Cytoplasm . Cytoplasm, cytosol . Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2 (PubMed:21030595). .
