FGF-2 Polyclonal Antibody
¥680.00
Pyruvate Dehydrogenase E2 mouse mAb
活动价：
¥880.00
市场价：¥1280.00
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产品规格：
- 50μL
货号：
FAB2601087
- 产品信息
商品描述
靶点-Target
Pyruvate Dehydrogenase E2
反应性
Human,Mouse
应用
WB,ICC,IP
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
69kD
推荐稀释比
WB 1:1000;ICC 1:300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human Pyruvate Dehydrogenase E2 protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of Pyruvate Dehydrogenase E2 and does not cross-react with related proteins.
基因名称
dlat
别名
70 kDa mitochondrial autoantigen of primary biliary cirrhosis;anti DLAT;Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex;Dihydrolipoamide;Dihydrolipoamide S Acetyltransferase;Dihydrolipoamide S-acetyltransferase;E2 component of pyruvate dehydrogenase complex;Dihydrolipoamide S-Acetyltransferase;Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex;dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial;DLAT;DLAT;DLTA;E2;E2 component of pyruvate dehydrogenase complex;M2 antigen complex 70 kDa subunit;M2 Antigen Complex 70kD Subunit;mitochondrial;ODP2_HUMAN;PBC;PDC E2;PDC-E2;PDCE2;Pyruvate dehydrogenase complex component E2;Pyruvate dehydrogenase complex E2 subunit;S acetyltransferase component of pyruvate dehydrogenase complex.
Organism-1
Human
基因ID-1
1737
SwissProt-1
P10515
Organism-2
Mouse
SwissProt-2
Q8BMF4
背景
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lact
细胞定位
Mitochondrion matrix.
