FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Beclin 1
反应性
Human,Mouse,Rat,Monkey,Hamster
应用
WB,IP
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
55kD
推荐稀释比
WB 1:1000;IP 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human Beclin 1 protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of Beclin 1 and does not cross-react with related proteins.
基因名称
becn1
别名
APG6;ATG 6;ATG6;ATG6 autophagy related 6 homolog;Bcl-2-interacting protein beclin;Beclin 1;coiled coil moesin like BCL2 interacting protein;Beclin 1 autophagy related;Beclin-1;Beclin1;BECN 1;BECN1;BECN1_HUMAN;Coiled coil myosin like BCL2 interacting protein;Coiled-coil myosin-like BCL2-interacting protein;GT197;Protein GT197;VPS 30;VPS30.
Organism-1
Human
基因ID-1
8678
SwissProt-1
Q14457
Organism-2
Mouse
SwissProt-2
O88597
背景
beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
细胞定位
Cytoplasm . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Mitochondrion membrane ; Peripheral membrane protein . Endosome . Cytoplasmic vesicle, autophagosome . Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). .; [Beclin-1-C 35 kDa]: Mitochondrion . Nucleus . Cytoplasm .; [Beclin-1-C 37 kDa]: Mitochondrion .
