FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CSK
反应性
Human,Rat
应用
WB,ICC
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
50kD
推荐稀释比
WB 1:1000;ICC 1:50
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human CSK protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of CSK and does not cross-react with related proteins.
基因名称
csk
别名
C SRC;C SRC kinase;C src Tyrosine Kinase;C-SRC kinase;c-src tyrosine kinase;Csk A;CSK;CSK_HUMAN;CYTOPLASMIC TYROSINE KINASE;MGC112926;MGC117393;MGC154049;P60 Src;Protein tyrosine kinase CYL;Protein-tyrosine kinase CYL;Proto oncogene tyrosine protein kinase;Tyrosine protein kinase CSK;Tyrosine protein kinase CSK;Tyrosine-protein kinase CSK;zgc:154049.
Organism-1
Human
基因ID-1
1445
SwissProt-1
P41240
Organism-2
Mouse
SwissProt-2
P41241
背景
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,
细胞定位
Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. .
