FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Raf-B
反应性
Human,Mouse
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
85kD
推荐稀释比
WB 1:1000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human B Raf protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of B Raf and does not cross-react with related proteins.
基因名称
braf
别名
FLJ95109;94 kDa B raf protein;B raf 1;B Raf proto oncogene serine threonine protein kinase;B-Raf proto-oncogene serine/threonine-protein kinase;p94;BRAF 1;BRAF;BRAF_HUMAN;BRAF1;cRmil;MGC126806;MGC138284;Murine sarcoma viral;v-raf;oncogene homolog B1;Murine sarcoma viral v raf oncogene homolog B1;NS7;oncogene BRAF1;p94;Proto-oncogene B-Raf;Proto-oncogene c-Rmil;RAFB 1;RAFB1;RMIL;Serine/threonine-protein kinase B-raf;v raf murine sarcoma viral oncogene homolog B;v raf murine sarcoma viral oncogene homolog B1;v-Raf murine sarcoma viral oncogene homolog B1
Organism-1
Human
基因ID-1
673
SwissProt-1
P15056
Organism-2
Mouse
SwissProt-2
P28028
背景
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Cytoplasm . Cell membrane . Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. .
