FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
HXK I
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
102kD
推荐稀释比
WB 1:1000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human Hexokinase 1 protein fragments expressed in E.coli
特异性
This antibody detects endogenous levels of Hexokinase 1 and does not cross-react with Hexokinase 2 and other proteins.
基因名称
hk1
别名
BB404130;Brain form hexokinase;dea;Glycolytic enzyme;HEXOKIN;Hexokinase PI;Hexokinase type I;Hexokinase, tumor isozyme;Hexokinase-1;Hexokinase-A;HK I;HK1;HK1 tb;Hk1-s;HK1-ta;HK1-tb;HK1-tc;HKD;HKI;HMSNR;HXK1;HXK1_HUMAN;mHk1-s.
Organism-1
Human
基因ID-1
3098
SwissProt-1
P19367
Organism-2
Mouse
SwissProt-2
P17710
背景
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016],
细胞定位
Mitochondrion outer membrane ; Peripheral membrane protein . Cytoplasm, cytosol . The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (Probable). Dissociates from the mitochondrial outer membrane following inhibition by N-acetyl-D-glucosamine, leading to relocation to the cytosol (PubMed:27374331). .
